Journal
BIOMEDICAL MATERIALS
Volume 10, Issue 3, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1748-6041/10/3/034004
Keywords
cardiac tissue engineering; biomaterials; host response; in vitro drug screening
Funding
- Heart and Stoke Foundation [GIA T6946]
- Canadian Institutes of Health Research (CIHR) Operating Grant [MOP-126027]
- NSERC Discovery Grant [RGPIN 326982-10]
- National Institutes of Health [2R01 HL076485]
- Canada Research Chair (Tier 2)
- Steacie Fellowship
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Cardiovascular disease is a leading cause of death worldwide, necessitating the development of effective treatment strategies. A myocardial infarction involves the blockage of a coronary artery leading to depletion of nutrient and oxygen supply to cardiomyocytes and massive cell death in a region of the myocardium. Cardiac tissue engineering is the growth of functional cardiac tissue in vitro on biomaterial scaffolds for regenerative medicine application. This strategy relies on the optimization of the complex relationship between cell networks and biomaterial properties. In this review, we discuss important biomaterial properties for cardiac tissue engineering applications, such as elasticity, degradation, and induced host response, and their relationship to engineered cardiac cell environments. With these properties in mind, we also emphasize in vitro use of cardiac tissues for high-throughput drug screening and disease modelling.
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