Journal
EXPERT REVIEW OF NEUROTHERAPEUTICS
Volume 18, Issue 5, Pages 395-406Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14737175.2018.1463160
Keywords
Amyotrophic lateral sclerosis; magnetic resonance imaging; atrophy; white matter damage; resting state functional connectivity; positron emission tomography; spinal cord imaging; network analysis
Categories
Funding
- Ministero della Salute, Italy [RF-2011-02351193]
Ask authors/readers for more resources
Introduction: Several neuroimaging techniques have been used to define in vivo markers of pathological alterations underlying amyotrophic lateral sclerosis (ALS). Growing evidence supports the use of magnetic resonance imaging (MRI) and positron emission tomography (PET) for the non-invasive detection of central nervous system involvement in patients with ALS. Areas covered: A comprehensive overview of structural and functional neuroimaging applications in ALS is provided, focusing on motor and extra-motor involvement in the brain and the spinal cord. Implications for pathogenetic models, patient diagnosis, prognosis, monitoring, and the design of clinical trials are discussed. Expert commentary: State-of-the-art neuroimaging techniques provide fundamental instruments for the detection and quantification of upper motor neuron and extra-motor brain involvement in ALS, with relevance for both pathophysiologic investigation and clinical practice. Network-based analysis of structural and functional connectivity alterations and multimodal approaches combining several neuroimaging measures are promising tools for the development of novel diagnostic and prognostic markers to be used at the individual patient level.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available