Journal
ACTA PHARMACEUTICA
Volume 65, Issue 2, Pages 105-116Publisher
HRVATSKO FARMACEUTSKO DRUSTOV (HFD)-CROATION PHARMACEUTICAL SOC
DOI: 10.1515/acph-2015-0019
Keywords
virosome; drug delivery system; cancer treatment; cancer vaccine
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Funding
- Jiangsu Specially-Appointed Professor Program
- Jiangsu Recruitment Program of Leading Creative and Entrepreneurial Talents
- National Natural Science Foundation [81402145, 31471294]
- Natural Science Foundation of Jiangsu Province [BK20140572]
- Start-up Scientific Research Fund for the Returned Oversea Scholars from the Chinese Ministry of Education
- Senior Talent Start-up Funds of Jiangsu University [14JDG050, 14JDG011]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (School of Pharmacy and Institute of Life Sciences of Jiangsu University)
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A virosome is an innovative hybrid drug delivery system with advantages of both viral and non-viral vectors. Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. Targeted drug delivery using virosome-based systems can be achieved through surface modifications of virosomes. A number of virosome-based prophylactic and therapeutic products with high safety profiles are currently available in the market. Cancer treatment is a big battlefield for virosome-based drug delivery systems. This review provides an overview of the general concept, preparation procedures, working mechanisms, preclinical studies and clinical applications of virosomes in cancer treatment.
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