Journal
NATURE REVIEWS CANCER
Volume 15, Issue 6, Pages 321-333Publisher
NATURE RESEARCH
DOI: 10.1038/nrc3932
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Funding
- Damon Runyon Cancer Research Foundation [DRSG-7-13]
- US National Cancer Institute (NCI) [R01CA163467]
- American Cancer Society [121635-RSG-11-175-01-RMC]
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MicroRNAs (mi-RNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor mi-RNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic. This, together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer.
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