Journal
EXPERT REVIEW OF ANTICANCER THERAPY
Volume 18, Issue 4, Pages 327-338Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14737140.2018.1438271
Keywords
Gastric; oesophageal; cancer; neoadjuvant; adjuvant; operable
Categories
Funding
- National Health Service
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Introduction: Treatment patterns for locally advanced operable gastric and oesophageal adenocarcinoma vary, with the optimal approach an area of debate within oncology. Strategies for treatment include a variety of neo-adjuvant, adjuvant and peri-operative regimens involving differing chemotherapy and radiotherapy combinations.Areas covered: This review will critically appraise the evidence base underpinning the main treatment approaches in operable oesophagogastric adenocarcinoma, highlighting variations in treatment by factors such as geographical area and primary tumor site.Expert commentary: The expert commentary will focus on the optimal evidence-based approaches for clinicians at the present time and explore how increased understanding of the molecular and genetic determinants of the disease may lead to refinements in treatment through the development of both biomarker-driven approaches and the application of novel targeted and immune-modulating agents to early treatment.
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