Related references
Note: Only part of the references are listed.The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on I-K1
Birgit Goversen et al.
PHARMACOLOGY & THERAPEUTICS (2018)
Stem Cell-Derived Models to Improve Mechanistic Understanding and Prediction of Human Drug-Induced Liver Injury
Christopher Goldring et al.
HEPATOLOGY (2017)
The role of declining adaptive homeostasis in ageing
Laura C. D. Pomatto et al.
JOURNAL OF PHYSIOLOGY-LONDON (2017)
Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross
Jessica B. Graham et al.
CELL REPORTS (2017)
Non-invasive cardiovascular imaging for evaluating subclinical target organ damage in hypertensive patients
Pasquale Perrone-Filardi et al.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING (2017)
Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification
Eugene K. Lee et al.
STEM CELL REPORTS (2017)
Assessment of Remote Heart Rhythm Sampling Using the AliveCor Heart Monitor to Screen for Atrial Fibrillation: The REHEARSE-AF Study
Julian P. J. Halcox et al.
CIRCULATION (2017)
Contextualization of drug-mediator relations using evidence networks
Hai Joey Tran et al.
BMC BIOINFORMATICS (2017)
In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia
Pei-Chi Yang et al.
JOURNAL OF PHYSIOLOGY-LONDON (2016)
Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform
Chris Denning et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)
The Fallacy of Assigning Chamber Specificity to iPSC Cardiac Myocytes from Action Potential Morphology
Christopher Kane et al.
BIOPHYSICAL JOURNAL (2016)
Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor
Mark L. Bannister et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
Pleiotropic mechanisms of action of perhexiline in heart failure
Christopher H. George et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2016)
Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia
Alan J. Williams et al.
JOURNAL OF PHYSIOLOGY-LONDON (2016)
Evolution of strategies to improve preclinical cardiac safety testing
Gary Gintant et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
A Systemized Approach to Investigate Ca2+ Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes
Aled R. Jones et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction
Monique J. Windley et al.
MOLECULAR PHARMACOLOGY (2016)
The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on RyR2
Mark L. Bannister et al.
CIRCULATION RESEARCH (2015)
Using quantitative systems pharmacology for novel drug discovery
Violeta I. Perez-Nueno
EXPERT OPINION ON DRUG DISCOVERY (2015)
Lessons learned from multi-scale modeling of the failing heart
Juan F. Gomez et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)
Synergy Between Intercellular Communication and Intracellular Ca2+ Handling in Arrhythmogenesis
Etienne Boileau et al.
ANNALS OF BIOMEDICAL ENGINEERING (2015)
A New System for Profiling Drug-Induced Calcium Signal Perturbation in Human Embryonic Stem Cell-Derived Cardiomyocytes
Kimberley J. Lewis et al.
JOURNAL OF BIOMOLECULAR SCREENING (2015)
Every Cell Is Special: Genome-wide Studies Add a New Dimension to Single-Cell Biology
Jan Philipp Junker et al.
CELL (2014)
The value of translational biomarkers to phenotypic assays
David C. Swinney
FRONTIERS IN PHARMACOLOGY (2014)
Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia
Derek S. Steele et al.
CARDIOVASCULAR RESEARCH (2013)
Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply
Markus B. Sikkel et al.
CARDIOVASCULAR RESEARCH (2013)
Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current
Markus B. Sikkel et al.
CARDIOVASCULAR RESEARCH (2013)
Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery
Ye Fang
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2013)
A network-oriented perspective on cardiac calcium signaling
Christopher H. George et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2012)
Ranolazine stabilizes cardiac ryanodine receptors: A novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2
Ashish Parikh et al.
HEART RHYTHM (2012)
Exploiting mathematical models to illuminate electrophysiological variability between individuals
Amrita X. Sarkar et al.
JOURNAL OF PHYSIOLOGY-LONDON (2012)
Interpreting noncoding genetic variation in complex traits and human disease
Lucas D. Ward et al.
NATURE BIOTECHNOLOGY (2012)
iPSC Disease Modeling
Frank Soldner et al.
SCIENCE (2012)
Computational Approaches for Analyzing Information Flow in Biological Networks
Boris Kholodenko et al.
SCIENCE SIGNALING (2012)
Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arrhythmia
Stephen A. Gaeta et al.
FRONTIERS IN PHYSIOLOGY (2012)
Cellular Decision Making and Biological Noise: From Microbes to Mammals
Gabor Balazsi et al.
CELL (2011)
Short Communication: Flecainide Exerts an Antiarrhythmic Effect in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia by Increasing the Threshold for Triggered Activity
Nian Liu et al.
CIRCULATION RESEARCH (2011)
Searching for new cardiovascular drugs: towards improved systems for drug screening?
Nicole C. Silvester et al.
EXPERT OPINION ON DRUG DISCOVERY (2011)
Electrophysiologic basis for the antiarrhythmic actions of ranolazine
Charles Antzelevitch et al.
HEART RHYTHM (2011)
Carnitine Palmitoyltransferase (CPT) Modulators: A Medicinal Chemistry Perspective on 35 Years of Research
Simona M. Ceccarelli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Functional Selectivity and Biased Receptor Signaling
Terry Kenakin
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
Christian van der Werf et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)
Cell-to-cell variability of alternative RNA splicing
Zeev Waks et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
How were new medicines discovered?
David C. Swinney et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Network medicine: a network-based approach to human disease
Albert-Laszlo Barabasi et al.
NATURE REVIEWS GENETICS (2011)
Genetic Variations Strongly Influence Phenotypic Outcome in the Mouse Retina
Austin S. Jelcick et al.
PLOS ONE (2011)
Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass
Fredrick A. Hilliard et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)
COMPLEX NETWORKS The fragility of interdependency
Alessandro Vespignani
NATURE (2010)
Not all noise is waste
Vito Quaranta et al.
NATURE METHODS (2010)
Systematizing Serendipity for Cardiovascular Drug Discovery
Peter J. Schlueter et al.
CIRCULATION (2009)
Temporal switching and cell-to-cell variability in Ca2+ release activity in mammalian cells
Naotoshi Nakamura et al.
MOLECULAR SYSTEMS BIOLOGY (2009)
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
Hiroshi Watanabe et al.
NATURE MEDICINE (2009)
Sarcoplasmic reticulum Ca2+ leak in heart failure:: mere observation or functional relevance?
Christopher H. George
CARDIOVASCULAR RESEARCH (2008)
Metabolic modulation with perhexiline in chronic heart failure - A randomized, controlled trial of short-term use of a novel treatment
L Lee et al.
CIRCULATION (2005)
Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina
BR Chaitman et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)
Network biology:: Understanding the cell's functional organization
AL Barabási et al.
NATURE REVIEWS GENETICS (2004)
Network motifs: Simple building blocks of complex networks
R Milo et al.
SCIENCE (2002)
Synchronization and rhythmic processes in physiology
L Glass
NATURE (2001)
Signaling networks: The origins of cellular multitasking
JD Jordan et al.
CELL (2000)
The large-scale organization of metabolic networks
H Jeong et al.
NATURE (2000)
The versatility and universality of calcium signalling
MJ Berridge et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)
Share Paper
