Journal
IMMUNITY INFLAMMATION AND DISEASE
Volume 3, Issue 2, Pages 94-102Publisher
WILEY
DOI: 10.1002/iid3.53
Keywords
Apoptosis; bone marrow; multiple myeloma; monocytes
Categories
Funding
- K.G. Jebsen Fund for Medical Research
- Cancer Society of Norway
- Health Research Fund
- Research Council of Norway [223255/F50]
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Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth and may play a role in the drug response. We therefore characterized monocytes in bone marrow aspirates by flow cytometry. We found that there was significant correlation between the proportion of CX3CR1(+), CD16(+)CD14 dim non classical monocytes, and percent plasma cells (PC) in the bone marrow of myeloma patients. The bone marrow monocytes could be stimulated by TLR ligands to produce cytokines which promote myeloma cell growth. The proportion of the non-classical monocytes increased with the tumor load, particularly in patients with tumor loads in the range of 10-30% bone marrow PC.
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