Journal
EUROPEAN JOURNAL OF NANOMEDICINE
Volume 7, Issue 3, Pages 169-179Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/ejnm-2014-0049
Keywords
alternative models; nanomaterials; risk assessment
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Funding
- Swiss National Science Foundation [320030_138365, PP00P2_123373]
- NRP64 program [406440131266/1, 4064-131232]
- Adolphe Merkle Foundation
- Swiss National Science Foundation through the National Centre of Competence in Research Bio-Inspired Materials
- Competence Centre for Materials Science and Technology (CCMX) Project Nano-screen
- Gebert-Ruf Stiftung [GRS-066/11]
- Swiss Commission for the Technology and Innovation [CTI 15794.1-PFLS-LS]
- Swiss National Science Foundation (SNF) [320030_138365] Funding Source: Swiss National Science Foundation (SNF)
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Engineered nanomaterials have unique and novel properties enabling wide-ranging new applications in nearly all fields of research. As these new properties have raised concerns about potential adverse effects for the environment and human health, extensive efforts are underway to define reliable, cost-and time-effective, as well as mechanistic-based testing strategies to replace the current method of animal testing, which is still the most prevalent model used for the risk assessment of chemicals. Current approaches for nanomaterials follow this line. The aim of this review is to explore and qualify the relevance of new in vitro and ex vivo models in (nano) material safety assessment, a crucial prerequisite for translation into applications.
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