Journal
EXPERIMENTAL EYE RESEARCH
Volume 171, Issue -, Pages 164-173Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2018.03.001
Keywords
Aqueous humor dynamics; Conventional outflow; Glaucoma; Intraocular pressure; Ocular hypertension
Categories
Funding
- NCI NIH HHS [P30 CA086862] Funding Source: Medline
- NEI NIH HHS [P30 EY000331, R01 EY026177, R01 EY027733, P30 EY016665, R01 EY017006, R01 EY026009, R01 EY011906, R01 EY019643, K99 EY022077, R01 EY021205, P30 EY021725, K08 EY024674, R01 EY026885, R21 EY027079, R00 EY022077, R01 EY026220, R01 EY025643, R21 EY028671, R01 EY026529, P30 EY005722, R01 EY026935, R01 EY026048] Funding Source: Medline
- NIGMS NIH HHS [R01 GM100909] Funding Source: Medline
- BLRD VA [I01 BX003938] Funding Source: Medline
- RRD VA [I01 RX001163, I50 RX003002] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA086862] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [R01EY026220, R01EY026885, R01EY019643, R21EY027079, R01EY025643, R21EY028671, R01EY011906, R01EY026009, R01EY026177, P30EY016665, R01EY027733, R01EY021205, R01EY023242, K99EY022077, K08EY024674, R01EY017006, P30EY005722, P30EY000331, R00EY022077] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM100909] Funding Source: NIH RePORTER
- Veterans Affairs [I01RX001163] Funding Source: NIH RePORTER
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Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular mechanisms involved in the regulation of conventional outflow resistance and thus intraocular pressure; and their dysfunction resulting in ocular hypertension. In this review, we describe the standard procedures used for the isolation of TM cells from several animal species including humans, and the methods used to validate their identity. Having a set of standard practices for TM cells will increase the scientific rigor when used as a model, and enable other researchers to replicate and build upon previous findings.
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