Journal
EXPERIMENTAL DERMATOLOGY
Volume 27, Issue 8, Pages 824-826Publisher
WILEY
DOI: 10.1111/exd.13478
Keywords
artificial sweat; damaged skin; stratum corneum
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In this study, we investigated how tannic acid (TA) protects the skin from inflammation caused by external irritation. The effects of TA were evaluated using a mouse 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced skin inflammation model and a reconstructed human epidermal model. We then used Lucifer Yellow for visual confirmation of TA's suppression effect at the stratum corneum (SC) surface. TA treatment of the skin prevented Lucifer Yellow from permeating the skin. This result suggests that TA acts as a barrier against external stimulants such as TPA and artificial sweat on the SC surface.
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