Journal
BIOMEDICAL MATERIALS
Volume 10, Issue 3, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1748-6041/10/3/034006
Keywords
cardiac tissue engineering; heart-on-a-chip; microfluidics; personalized medicine
Funding
- Defense Threat Reduction Agency (DTRA) under Space and Naval Warfare Systems Center Pacific (SSC PACIFIC) [N66001-13-C-2027]
- Office of Naval Research Young National Investigator Award
- National Institutes of Health [EB012597, AR057837, DE021468, HL099073, R56AI105024]
- Presidential Early Career Award for Scientists and Engineers (PECASE)
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The heart is one of the most vital organs in the human body, which actively pumps the blood through the vascular network to supply nutrients to as well as to extract wastes from all other organs, maintaining the homeostasis of the biological system. Over the past few decades, tremendous efforts have been exerted in engineering functional cardiac tissues for heart regeneration via biomimetic approaches. More recently, progress has been made toward the transformation of knowledge obtained from cardiac tissue engineering to building physiologically relevant microfluidic human heart models (i.e. heart-on-chips) for applications in drug discovery. The advancement in stem cell technologies further provides the opportunity to create personalized in vitro models from cells derived from patients. Here, starting from heart biology, we review recent advances in engineering cardiac tissues and heart-on-a-chip platforms for their use in heart regeneration and cardiotoxic/cardiotherapeutic drug screening, and then briefly conclude with characterization techniques and personalization potential of the cardiac models.
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