Journal
WIENER MEDIZINISCHE WOCHENSCHRIFT
Volume 165, Issue 11-12, Pages 258-261Publisher
SPRINGER WIEN
DOI: 10.1007/s10354-015-0355-8
Keywords
Prenylflavonoids; 6-Prenylnaringenin; 8-Prenylnaringenin; Nutrition; Cancer
Categories
Funding
- Wissenschaftsfoerderung der Deutschen Brauwirtschaft e.V. [B103]
- Pascoe pharmazeutische Praeparate GmbH
- Else Uebelmesser Foundation
- German Childhood Cancer Foundation
- Innovation Grant of the University of Tuebingen
Ask authors/readers for more resources
Flavonoids form a substantial group of secondary plant metabolites that display several health-promoting effects. Therefore, prenylflavonoids, a subclass of flavonoids, have attracted increasing attention. Here, we investigated the possible anti-cancer potential of 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN), two prenylflavonoids present in hops and beer and demonstrate an unexpectedly pronounced, dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and UO.31 renal carcinoma cells upon treatment. Based on these findings 6-PN and 8-PN are currently further clinically evaluated in detail.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
