Journal
EXPERIMENTAL CELL RESEARCH
Volume 364, Issue 1, Pages 95-103Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2018.01.035
Keywords
Acinetobacter baurnannii; hLF(1-11); Caspase-1; Pyroptosis
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Funding
- National Natural Science Foundation of China [81770080]
- Xiangya Hospital-BeidaWeiming Clinical Rehabilitation Research Fund [XYWM2015I20]
- Innovation Project of Central South University [2017zzts832]
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Acinetobacter bawnannii is a Gram-negative coccobacillus found primarily in hospital settings that has recently emerged as a source of hospital-acquired infections, including bacterial pneumonia. The hLF(1-11) peptide comprising the first 11 N-terminal residues of human lactoferrin exerts antimicrobial activity in vivo and was highly effective against multidrug-resistant A. baumannii strains in vitro and in vivo. Pyroptosis is a caspase-1-dependent inflammatory cell death process and is induced by various microbial infections. In the present study, we investigated the molecular mechanisms that regulate pyroptosis induced by A. baumannii in macrophages. Our results revealed that A. baumannii induced pyroptosis through caspase-1 activation and IL-1 beta production. We also found that caspase-1 activation and IL-1 beta maturation in A. baumannii-triggered pyroptotic cell death were reduced by hLF(1-11) treatment. Moreover, hLF(1-11) inhibited the A. bawnannii-induced caspase-1 activation and pyroptosis of pulmonary alveolar macrophages in vivo.
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