Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 46, Issue 4, Pages 205-214Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000158
Keywords
muscle atrophy; diaphragm; ventilator-induced diaphragm dysfunction; weaning; reactive oxygen species
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Funding
- National Institutes of Health [NIH R01 AR064189]
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The renin-angiotensin system (RAS) plays a key role in the control of blood pressure and fluid homeostasis. Emerging evidence also reveals that hyperactivity of the RAS contributes to skeletal muscle wasting. This review discusses the key role that the RAS plays in skeletal muscle wasting due to congestive heart failure, chronic kidney disease, and ventilator-induced diaphragmatic wasting.
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