Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 46, Issue 2, Pages 92-96Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000142
Keywords
hippo signaling pathway; yes-associated protein (Yap); transcriptional co-activator with PDZ-binding motif (Taz); skeletal muscle; exercise-induced hypertrophy
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Funding
- Diabetes Australia general grant [Y16G-WATK]
- Australian National Health and Medical Research Council (NHMRC) [1099588]
- National Institutes of Health [AR057347, AR063256]
- NHMRC
- Operational Infrastructure Support Program of the Victorian Government
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR057347] Funding Source: NIH RePORTER
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The Hippo signaling pathway regulates the activity of the proteins Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (Taz) to control tissue growth in many different cell types. Previously, we demonstrated that Yap is a critical regulator of skeletal muscle mass. We hypothesize that alterations in Yap and Taz activity modulate the anabolic adaptations of skeletal muscle to resistance exercise.
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