Journal
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
Volume 2018, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2018/3610364
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Seven out of eightmethanolic extracts fromfive plants native toMexico were inactive against ten bacterial strains of clinical interest. The fruit extract of Chenopodium ambrosioides inhibited the bacteria Enterococcus faecalis (MIC = 4375 mu g/ml), Escherichia coli (MIC = 1094 mu g/ml), and Salmonella typhimurium (MIC = 137 mu g/ml). Thefruit extract of C. ambrosioides was with CC50 = 45 mu g/ml most cytotoxic against the cell-line Caco-2, followed by the leaf extract from Pithecellobium dulce (CC50 = 126 mu g/ml); interestingly, leaves of C. ambrosioides (CC50 = 563 mu g/ml) and bark of P. dulce (CC50 = 347 mu g/ml) extracts weremuch less cytotoxic. We describe for the first time the cytotoxic effect from extracts of the aerial parts and the flowers of Cirsium mexicanum (CC50 = 323 mu g/ml and CC50 = 250 mu g/ml, resp.). Phytochemical analysis demonstrated for both extracts high tannin and saponin and low flavonoid content, while terpenoids were found in the flowers. For the first time we report a cytotoxicological study on an extract of Eryngium carlinae (CC50 = 356 mu g/ml) and likewise the bark extract from Amphipterygium adstringens (CC50 = 342 mu g/ml). In conclusion the fruit extract of C. ambrosioides is a potential candidate for further biological studies.
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