Journal
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
Volume 23, Issue 8, Pages 818-828Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jagp.2014.10.001
Keywords
Metabolic syndrome; sleep complaints; elderly; observational study
Categories
Funding
- UCB Pharma
- Jazz Pharmaceutical
- Bioprojet
- Lesieur
- Bausch Lomb
- Aprifel
- Danone Institute
- Canadian Association of Gerontology
- Jean Mayer Human Nutrition Research Center on Aging, Tufts University
- Vifor Pharma
- Danone
- Agence Nationale de la Recherche
- Conseil Regional d'Aquitaine
- Institut Carnot LISA
- Groupe Lipides et Nutrition
- Medical Research Council [K013351]
- Academy of Finland
- ESRC
- Languedoc-Roussillon Region (Chercheur d'avenir grant)
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- MGEN
- Institut de la Longevite
- Agence Francaise de Securite Sanitaire des Produits de Sante
- Regional Government of Aquitaine
- Regional Government of Bourgogne
- Regional Government of Languedoc-Roussillon
- Fondation de France
- Ministry of Research-INSERM Programme 'Cohorts and collection of biological material'
- Novartis
- Medical Research Council [MR/K013351/1] Funding Source: researchfish
- MRC [MR/K013351/1] Funding Source: UKRI
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Objectives: To assess whether sleep complaints (rather than clinically defined sleep disturbances) were associated with the metabolic syndrome (MetS) and each of its components in an elderly population. Methods: Cross-sectional analyses of data from the French Three City Study, a large multicenter cohort of elderly community-dwellers. Participants: 6,354 participants (56.4% women, median age 73; range: 65-97 years). Measurements: Frequency of insomnia complaints (difficulty in initiating sleep, difficulty in maintaining sleep [DMS], and early morning awakening) and excessive daytime sleepiness (EDS) were self-reported. MetS was assessed using National Cholesterol Education program Adult Treatment Panel III criteria. Results: A total of 977 participants had MetS. After adjustment for a large range of potential confounders, we report an association between the number of insomnia complaints and MetS. Among insomnia complaints only DMS was consistently associated with MetS (OR: 1.23, 95% CI: 1.06 to 1.43). Our results showed that EDS independently increased the risk of MetS (OR: 1.46, 95% CI: 1.18 to 1.81 for frequently; OR: 1.99, 95% CI: 1.49 to 1.67 for often). The EDS-MetS association was independent of past-history of cardiovascular disease, insomnia complaints, and obesity and loud snoring. Conclusion: We report significant independent associations between frequent sleep complaints (EDS and to a lesser extent DMS) and MetS in the elderly with potential implications in terms of management and cardiovascular prevention in general geriatric practice. Prospective studies are required to clarify the direction of the association between sleep complaints and MetS.
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