Journal
EUROPEAN PSYCHIATRY
Volume 50, Issue -, Pages 47-56Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.eurpsy.2017.12.006
Keywords
Psychiatric disorder; Dementia; Economics and psychiatry; Epidemiology; MRI; Neurodevelopment
Categories
Funding
- EU [732592]
- Lundbeck Foundation [R186-2015-2138] Funding Source: researchfish
- Medical Research Council [MC_UP_1401/1, MC_UU_00005/9] Funding Source: researchfish
- Wellcome Trust [107392/A/15/Z] Funding Source: researchfish
- MRC [MC_UU_00005/9, MC_UP_1401/1] Funding Source: UKRI
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The main objective of Lifebrain is to identify the determinants of brain, cognitive and mental (BCM) health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the life span, we will merge fine-grained BCM health measures of more than 5000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive and mental health measures for the broader cohorts, exceeding 27,000 examinations in total. By linking these data to other databases and biobanks, including birth registries, national and regional archives, and by enriching them with a new online data collection and novel measures, we will address the risk factors and protective factors of BCM health. We will identify pathways through which risk and protective factors work and their moderators. Exploiting existing European infrastructures and initiatives, we hope to make major conceptual, methodological and analytical contributions towards large integrative cohorts and their efficient exploitation. We will thus provide novel information on BCM health maintenance, as well as the onset and course of BCM disorders. This will lay a foundation for earlier diagnosis of brain disorders, aberrant development and decline of BCM health, and translate into future preventive and therapeutic strategies. Aiming to improve clinical practice and public health we will work with stakeholders and health authorities, and thus provide the evidence base for prevention and intervention. (c) 2018 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY-NCND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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