Journal
EUROPEAN POLYMER JOURNAL
Volume 99, Issue -, Pages 117-133Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2017.12.004
Keywords
Smart hydrogels; Functional approach; Drug delivery systems; Dynamic interactions; Functional biomaterials; Responsiveness
Categories
Funding
- Fundacao de Amparo e Pesquisa do Estado de Sao Paulo (FAPESP)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Ferring Pharmaceuticals
- INCT-NANOFARMA
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This review discusses basic aspects used to control the architecture and functional properties of smart hydrogels. The introduction briefly outlines what has been accomplished regarding smart hydrogels and explores historical aspects and the fundamental understanding of these systems. Then, a short discussion on the chemical interactions and the main variables involved in architectural construction is exhibited. Further analysis provides the basis for optimizing biological responses through system modulation. Finally, we outline perspectives and challenges for building smart hydiogels into functionalized and modulated delivery systems.
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