Journal
EUROPEAN POLYMER JOURNAL
Volume 103, Issue -, Pages 260-270Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2018.04.020
Keywords
Biocompatibility; Breast cancer; Tamoxifen; Folate receptor; Drug delivery
Categories
Funding
- Faculty of Pharmacy, Zanjan of Medical Sciences [A-12-430-28]
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Amphiphilic FA-L-PEG-PCL (PEG: Poly ethylene glycol-hydrophilic segment, FA: Folic acid-targeting agent, L: Lysine-linker, PCL: Poly caprolactone-hydrophobic segment) copolymer was synthesized. Proton nuclear magnetic resonance (HNMR), Fourier-transform infrared spectroscopy (FT-IR), Dynamic light scattering (DLS), atomic force microscopy (AFM), dynamic scanning colorimetry (DSC) were used for characterization of synthesizes copolymers. For determining cytotoxicity of our copolymers, we used from MTT assay, Hemolysis assay and lethal dose 50 (LD50) test. These tests revealed that copolymers had least in vitro and in vivo cytotoxicity and they are categorized as practically none toxic. These copolymers were self-assembled into Round-shaped folate-functionalized micelles in aqueous medium for the folate receptor (FR)-mediated targeted delivery of Tamoxifen (TMX)-the anticancer drug-to cancer cells. The drug loading capacity and in vitro pH responsive controlled release performance showed that these micelles had potential as drug delivery systems (DDS) for hydrophobic anti-cancer drugs such as TMX. FA-L-PEG-PCL micelles was non-cytotoxic in high concentrations. Loaded-TMX micelles obviously showed an increase in killing of the cancer cells.
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