Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 46, Issue 1, Pages 55-61Publisher
IOS PRESS
DOI: 10.3233/JAD-150088
Keywords
Alzheimer's disease; amyloid; antibodies; ceramide; exosomes; mice
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Funding
- National Institutes of Health [R01-AG034389, F32-AG044954]
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We present evidence that 5XFAD Alzheimer's disease model mice develop an age-dependent increase in antibodies against ceramide, suggesting involvement of autoimmunity against ceramide in Alzheimer's disease pathology. To test this, we increased serum anti-ceramide IgG (2-fold) by ceramide administration and analyzed amyloid plaque formation in 5XFAD mice. There were no differences in soluble or total amyloid-beta levels. However, females receiving ceramide had increased plaque burden (number, area, and size) compared to controls. Ceramide-treated mice showed an increase of serum exosomes (up to 3-fold using Alix as marker), suggesting that systemic anti-ceramide IgG and exosome levels are correlated with enhanced plaque formation.
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