Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 834, Issue -, Pages 188-196Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2018.07.034
Keywords
Molecular targeted therapy; Cancer; Small molecule; Monoclonal antibody; Therapeutic cancer vaccine; Gene therapy
Categories
Funding
- FRGS [203/CIPPM/6711542]
- L'Oreal-UNESCO for Women in Science Fellowship [304/CIPPM/650806/L117]
- MAKNA Cancer Research Award [304/CIPPM/650859]
- USM Graduate Assistant Scheme
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Molecular targeted therapies are revolutionized therapeutics which interfere with specific molecules to block cancer growth, progression, and metastasis. Many molecular targeted therapies approved by the Food and Drug Administration (FDA), have demonstrated remarkable clinical success in the treatment of a myriad of cancer types including breast, leukemia, colorectal, lung, and ovarian cancers. This review provides an update on the different types of molecular targeted therapies used in the treatment of cancer, focusing on the fundamentals of molecular targeted therapy, its mode of action in cancer treatment, as well as its advantages and limitations.
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