Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 127, Issue -, Pages 112-119Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2018.02.009
Keywords
Metal-organic framework; gamma-cyclodextrin; Drug adsorption; Drug delivery; Anti-inflammatory in vivo assay
Categories
Funding
- Sao Paulo Research Foundation - FAPESP [2014/10888-1]
- National Council for Scientific and Technological Development - CNPq
- Coordination for the Improvement of Higher Education Personnel - CAPES
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Drug delivery systems have been used to reduce adverse effects and improve the efficacy of therapies. Drug carriers have been developed over the years, but they have limitations. gamma-cyclodextrin-based metal-organic frameworks (gamma-CD-MOF) have significant advantages due to their biocompatibility and environmental safety, besides crystallinity and porosity. Herein, gamma-CD-MOFs were synthesised with different metals as nodes and investigated. Uniform mesoporous gamma-CD-MOFs were obtained and showed an absence of toxicity in HepG2 and Caco-2 cells. The longer controlled release was verified for gamma-CD-MOFs, with a maximum of 62% released in 12 h. An inflammation experiment was performed in mice and activity equivalent to the positive control was verified. gamma-KCD-MOFs and gamma-NaCD-MOFs reached activity after 6 h of administration, however this happened after 24 h in gamma-FeCD-MOFs, being more effective than the positive control. Considering the ability for drug entrapment, easy preparation and controlled release, this class of material allows potential applications in drug delivery systems.
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