Journal
NATURE REVIEWS CANCER
Volume 15, Issue 7, Pages 440-448Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3949
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Funding
- US National Institutes of Health [CA157996]
- Cancer Prevention and Research Institute of Texas [RP130272]
- European research program [CIG618113, ERC614204]
- Israel Science Foundation [1343/13, 1952/13]
- Minerva grant award [711730]
- Adelis Foundation
- Henry S. and Anne S. Reich Research Fund
- Dukler Fund for Cancer Research
- Paul Sparr Foundation
- Saul and Theresa Esman Foundation
- estate of Fannie Sherr
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Cancer is a prime example of a disease process in which carcinogenic and metabolic changes are intertwined to promote cell survival and growth. One approach to unravel this complex relationship is by studying rare, monogenic disorders caused by mutations in genes encoding metabolic enzymes or regulators. There are hundreds of these diseases, most of which manifest in childhood and are collectively termed 'inborn errors of metabolism' (IEMs). Several IEMs demonstrate the consequences of chronic, systemic loss of a particular metabolic activity that can result in malignancy. In this Opinion article, we present a conceptual categorization of IEMs associated with cancer and discuss how assessment of these rare diseases might inform us about the biological foundations of common types of cancer and opportunities for cancer diagnosis and therapy.
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