Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 117, Issue -, Pages 48-54Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejps.2018.02.011
Keywords
Curcumin; alpha-Glucosyl stevia; Polyvinylpyrrolidone K-30; Composite; Dissolution enhancement; Jelly formulation
Categories
Funding
- Salt Science Research Foundation [1651]
Ask authors/readers for more resources
Curcumin (CUR) solutions prepared with alpha-glucosyl stevia (Stevia-G) and polyvinylpyrrolidone K-30 (PVP) by evaporation method showed 11,000-fold higher solubility compared to CUR alone. Tri-component formulations of CUR/Stevia-G/PVP in aqueous solution showed improved CUR stability for precipitation-triggering conditions of CUR, such as aqueous dilution and temperature changes. Fluorescence study with CUR and pyrene indicated that Stevia-G/PVP mixed solutions produce a more hydrophilic microenvironment around their molecules with increasing PVP concentration compared to Stevia-G solution alone. These results suggested the composite formation associated with the adsorption of the aggregated structure of Stevia-G onto PVP molecules. Jelly formulations were prepared with kappa-carrageenan, and jelly formulations containing nanocomposites formed by CUR/Stevia-G/PVP obviously enhanced the dissolution properties of CUR compared to CUR powder. This result indicated that the composite formed by CUR/Stevia-G/PVP could be maintained even after the preparation of jelly and release into a dissolution media. Production of jelly formulations using Stevia-G and PVP are a promising way to improve the dissolution properties of CUR.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available