Journal
EUROPEAN JOURNAL OF PEDIATRICS
Volume 177, Issue 9, Pages 1317-1325Publisher
SPRINGER
DOI: 10.1007/s00431-018-3188-9
Keywords
Allergy; Asthma; Atopic dermatitis; Atopic march; Questionnaire; Rhino conjunctivitis
Categories
Funding
- Agency for International Science and Technology Cooperation
- US-SR Science and Technology Program [012/95]
- project of the National Health Promotion Program [23]
- Ministry of Education Youth and Sports the Czech Republic [LM2015051, CZ.02.1.01/0.0/0.0/15_003/0000469]
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Allergic diseases have increased in developed countries during the past decades. A cohort of Slovak children was followed from birth to track allergic symptoms dynamics in early childhood. Information on allergic symptoms (atopic dermatitis = AD, rhino conjunctivitis = RC, wheezing = Wh, urticaria = Ur) and food allergies among children was based on clinical evaluation of children by allergists at three developmental stages (infant, toddler, preschool). Out of 320 cases of allergies, 64 infants, 145 toddlers, and 195 preschool children suffered from AD, RC, Wh, Ur, or their combinations (i.e., significant increase with age, p < 0.001). AD first appeared in infants, Wh and/or RC rose mainly in toddlers, and Ur among preschool children. AD in infants or toddlers disappeared in the subsequent developmental stage in approximately one third of all cases. Single AD persistence without remission or extension was not common and accounted only for 6.9% of AD infants' allergic manifestations. In addition to single-symptom allergic diseases, this study also identified several combinations of atopic symptoms. Conclusions: The proportion of multi-symptom allergies increased while single-symptom forms decreased. The observed temporal trends of allergic symptoms correspond to the atopic march.
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