Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2018, Issue 20-21, Pages 2352-2365Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201800109
Keywords
Cross-coupling; N-C activation; Amides; Twisted amides; Decarbonylative coupling
Categories
Funding
- Rutgers University
- National Science Foundation (NSF) [CAREER CHE-1650766]
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In this Microreview, we describe the recent exciting developments in the burgeoning area of amide N-C cross-coupling enabled by amide bond twist of N-acyl-glutarimides. Since the initial reports in 2015, these amides have been demonstrated to be by far the most reactive amide derivatives in the biologically-relevant manifold of N-C activation/cross-coupling, thus stimulating the development of more than 10 previously unknown catalytic modes of reactivity of the amide bond. The capacity of N-acyl-glutarimides as privileged scaffolds to expedite acyl and decarbonylative cross-couplings by amide N-C cleavage is discussed.
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