Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2018, Issue 35, Pages 4828-4844Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201800852
Keywords
Schwartz's reagent; Hydrozirconation; Metallocenes; Enantioselectivity; Asymmetric synthesis
Categories
Funding
- FAPEMIG
- CAPES
- CNPq
- Rede Mineira de Quimica
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Organozirconium chemistry has been widely employed in organic synthesis since its discovery in the last century. In this context, Schwartz's reagent stands out as a powerful tool that has been applied in several chemical transformations. This chemistry has attracted considerable attention due to its versatility, allowing chemoselective C-C, C-N, and C-X bond formation, as well as hydrozirconation. The reagent is in fact a zirconium-containing metallocene, which is compatible with the presence of various metals in cross-coupling reactions. Enantioselective transformations of organozirconium are described here, which have recently found wide applications in total synthesis. Furthermore, aspects covering ring-closure reactions, affording complex stereoenriched cycles and heterocycles, such as substituted cyclopropanes and pyrrolidines, are hereby disclosed.
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