Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2018, Issue 22, Pages 2817-2821Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201800162
Keywords
Nitrogen heterocycles; Polycycles; Friedel-Crafts reaction; Cyclization; Synthetic methods
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Funding
- DoP, Ministry of Chemicals & Fertilizers, Govt. of India, New Delhi
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A methodology for the synthesis of indolo[1,2-b]isoquinoline derivatives by Lewis acid-catalyzed intramolecular Friedel-Crafts alkylation reaction has been developed. The reaction proceeds well with both secondary and primary 2-indolylmethanols. The method efficiently affords pharmaceutically important polycyclic fused indole derivatives in moderate to high yields with good functional group tolerance. In addition, the reaction proceeded in large scale indicating that this method could be scaled up for the synthesis of indolo[1,2-b] isoquinoline derivatives.
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