Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2018, Issue 10, Pages 1241-1247Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201701618
Keywords
Synthetic methods; Nitrogen heterocycles; Polycycles; Domino reactions; Copper
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Funding
- Ministry of Science and Technology of the Republic of China [MOST 103-2113-M-003-008-MY3]
- National Taiwan Normal University [103-07-C]
- Instrumentation Centre at National Taiwan Normal University
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A one-pot reaction has been devloped for the preparation of 1,2,3-fused indole polyheterocycles by starting from 2-iodobenzamide and 2-iodobenzyl cyanide in the presence of a copper catalyst. The cascade process involves the efficient formation of one C-C and three C-N bonds. A broad substrate scope, good yields, and short reactions times are key features of this strategy.
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