Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2018, Issue 10, Pages 1277-1280Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201800117
Keywords
Cyclic ketones; Tetrahydroisoquinolines; Organocatalysis; Photocatalysis; Alkylation
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Funding
- Chinese Scholarship Council
- European Research Council under the European Union's Seventh Framework Programme (FP)/ ERC Grant [617044]
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The asymmetric -alkylation of tetrahydroisoquinolines with cyclic ketones has been accomplished in the presence of a combined catalytic system consisting of a visible-light photoredox catalyst and a chiral primary amine organocatalyst. The desired products were obtained in good yields, high enantioselectivity, and good to excellent diastereoselectivity. (PC: photoredox cycle, EN: enamine cycle).
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