Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2018, Issue 20-21, Pages 2554-2560Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201800046
Keywords
Oxygen heterocycles; Palladium; Homogeneous catalysis; Cyclization; Synthetic methods
Categories
Funding
- Polish National Science Centre [DEC-2016/22/E/ST5/00537]
- Polish Ministry of Science and Higher Education
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We report an efficient protocol for the synthesis of 2,3,5-trisubstituted furans through the reaction of readily available -acetylenic -keto esters with aryl and heteroaryl bromides. The reaction, which involves a 5-exo-dig cyclization, coupling, and isomerization of a double bond, proceeds smoothly with very low catalyst loading (0.1 mol-%), and shows excellent functional-group tolerance.
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