Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 44, Pages 24733-24740Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b07453
Keywords
collagen protein; colloidal gold nanoparticles; core-shell nanoconjugates; layer-by-layer assembly; cell adhesion and growth
Funding
- National Natural Science Foundation of China [21522307, 21473208, 91434103, 21473153]
- Talent Fund of the Recruitment Program of Global Youth Experts
- CAS visiting professorships for senior international scientists [2015VTA033]
- Chinese Academy of Sciences (CAS)
- Natural Science Foundation of Hebei Province [B2013203108]
- Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province [YQ2013026]
- Support Program for the Top Young Talents of Hebei Province
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The biogenic synthesis of biomolecule-gold nanoconjugates is of key importance for a broad range of biomedical applications. In this work, a one-step, green, and condition-gentle strategy is presented to synthesize stable colloidal-gold collagen core-shell nanoconjugates in an aqueous solution at room temperature, without use of any reducing agents and stabilizing agents. It is discovered that electrostatic binding between gold ions and collagen proteins and concomitant in situ reduction by hydroxyproline residues are critically responsible for the formation of the core shell nanoconjugates. The film formed by layer-by-layer assembly of such colloidal gold-collagen nanoconjugates can notably improve the mechanical properties and promote cell adhesion, growth, and differentiation. Thus, the colloidal gold-collagen nanoconjugates synthesized by such a straightforward and clean manner, analogous to a biomineralization pathway, provide new alternatives for developing biologically based hybrid biomaterials toward a range of therapeutic and diagnostic applications.
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