Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 146, Issue -, Pages 395-408Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.12.093
Keywords
Photodynamic therapy; Melanoma; Chlorins; Photosensitizer; Photophysics
Categories
Funding
- Portuguese Agency for Scientific Research, Fundacao para a Ciencia e a Tecnologia (FCT)
- FEDER through the COMPETE-UE [POCI-01-0145-FEDER-PTDC/QEQ-MED/0262/2014, UID/NEU/04539/2013]
- Coimbra Chemistry Centre (CQC) [POCI-01-0145-FEDER-007630]
- CNC.IBILI [POCI-01-0145-FEDER-007440]
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The synthesis, photophysical behaviour and photosensitization ability of novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused 5,15-diphenylchlorins against melanoma cells are described. All studied chlorins were found to be extremely active against melanoma cell lines A375 showing IC50 values below 20 nM. Furthermore, a dihydroxymethyl diphenylchlorin was identified as an excellent candidate to allow modulating of different types of cell death, apoptosis vs. necrosis, by varying its concentration. This can be explored as a tool to improve the effectiveness of PDT since inflammatory response resulting from necrotic cell death after PDT can activate the antitumor immune response with implications also regarding the vascular damage. This feature combined with very low cytotoxicity against human melanoma cells in the absence of light activation and against human fibroblast HFF-1 cells makes this chlorin a candidate of choice as a photosensitizer for PDT. A comprehensive photophysical investigation including the determination of quantum yields for fluorescence, singlet oxygen sensitization and internal conversion, lifetimes and rate constants of all the excited state deactivation processes has been undertaken. (C) 2018 Elsevier Masson SAS. All rights reserved.
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