Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 143, Issue -, Pages 542-557Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.11.064
Keywords
Quinoxaline; Biological applications; Anti-cancer; Antimalarial; Anti-inflammatory; Antimicrobial
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Quinoxaline, a fused heterocycle of benzene and pyrazine rings has gained considerable attention in the field of contemporary medicinal chemistry. The moiety is of substantial importance because of its wide array of pharmacological activities viz. anti-cancer, antimalarial, anti-inflammatory, antimicrobial, anti HIV etc. Diversely substituted quinoxalines are important therapeutic agents in the pharmaceutical industry. This review focusses on the quinoxaline derivatives developed during the last decennial period and their biomedical applications. A compilation of patents on quinoxaline is also included herein. (C) 2017 Elsevier Masson SAS. All rights reserved.
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