Journal
EUROPEAN JOURNAL OF INTERNAL MEDICINE
Volume 47, Issue -, Pages 6-13Publisher
ELSEVIER
DOI: 10.1016/j.ejim.2017.08.019
Keywords
Cancer; Immunotherapy; Endocrinopathies; Hypophysitis; Thyroiditis; Adrenalitis; Type 1 diabetes
Categories
Ask authors/readers for more resources
Cancer immunotherapy has proven to be effective in a wide variety of tumors. The use of immune checkpoint blocking monoclonal antibodies has become a standard treatment regimen in some of them as advanced melanoma. However, given the mechanism of action, its use may be associated with immune-related adverse events that may complicate the clinical course and prognosis of patients. Among these are autoimmune endocrine adverse effects, such as hypophysitis, hypo and hyperthyroidism, and adrenal insufficiency. This review focuses on the most relevant and new aspects related to the incidence, clinical presentation, diagnosis and treatment of these adverse effects associated with different types of immune checkpoint inhibitors in cancer immunotherapy. (c) 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available