Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 14, Pages 1589-1594Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201800055
Keywords
Platinum; Antitumor agents; N,O ligands; Cytotoxicity; Alkylation
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Funding
- Universita di Pisa (Fondi di Ateneo)
- Ministero dell'Universita e della Ricerca (MIUR)
- Interuniversity Consortium CHEMICAL REACTIVITY and CATALYSIS (CIRCC)
- Universita di Pisa - Progetti di Ricerca di Ateneo Composti di metalli di transizione come possibili agenti anti-tumorali [PRA_2017_25]
- Dipartimento di Scienze del Farmaco, Universita di Padova Progetti di Ricerca di Dipartimento -PRID- An in depth investigation on novel Pt-based agents to shed light on cancer resistance mechanisms
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Two new platinum(II) complexes bearing triphenylphosphine and bidentate oxime ligands [Pt(Cl)(PPh3){(kappa(2)-N,O)-(1{C(R)=N(OH)-2(O)C10H6})}] (R = H, Me) were synthesized in good yields from trans-[PtCl(mu-Cl)(PPh3)](2). The structure of [Pt(Cl)(PPh3){(kappa(2)-N,O)-(1{CH=N(OH)-2(O)C10H6})}] was determined by single-crystal X-ray diffraction. Both complexes showed good antiproliferative properties in vitro against HeLa, A2780, and A2780cis cancer cell lines. They reacted cleanly with alkylating agents in the presence of aqueous bases under phase-transfer catalysis conditions to afford the corresponding O-alkylation products [Pt(Cl)(PPh3){(kappa(2)-N,O)-(1{HC=N(OR')-2(O) C10H6})}] [R'=CH2CH2Cl, CH2Ph, (CH2)(4)Br] in good yields.
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