Journal
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Volume 48, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/eci.12964
Keywords
calcium channels; calcium signalling; CRAC channels; leucocyte recruitment cascade; neutrophil; Orai1; P2X receptors; potassium channels; SOCE; STIM1; TRP channels
Funding
- Deutsche Forschungsgemeinschaft [SFB914]
- National Institute of Allergy and Infectious Diseases [AI047924, AI129302]
- United States National Institute of Health [AI047924, AI129302]
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The recruitment of neutrophils to sites of inflammation, their battle against invading microorganisms through phagocytosis and the release of antimicrobial agents is a highly coordinated and tightly regulated process that involves the interplay of many different receptors, ion channels and signalling pathways. Changes in intracellular calcium levels, caused by cytosolic Ca2+ store depletion and the influx of extracellular Ca2+ via ion channels, play a critical role in synchronizing neutrophil activation and function. In this review, we provide an overview of how Ca2+ signalling is initiated in neutrophils and how changes in intracellular Ca2+ levels modulate neutrophil function.
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