Journal
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Volume 48, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/eci.12949
Keywords
clearance; CXCR4; mobilization; neutrophils; retention
Funding
- Wellcome Trust [201356/Z/16/Z]
- Wellcome Trust [201356/Z/16/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
Background Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease. Results Conclusion The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes. In this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone marrow for clearance under homeostasis and disease. We also discuss the role of CXCR4 in fine-tuning neutrophil responses in the context of inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
