Journal
PSYCHIATRIC CLINICS OF NORTH AMERICA
Volume 38, Issue 2, Pages 295-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.psc.2015.01.008
Keywords
Genetic counseling; Predictive genetic testing; Presymptomatic testing protocol; Huntington disease; Alzheimer disease; Frontotemporal degeneration; CADASIL; Prion disease
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Funding
- NIH/NIA [P50 AG08702, R01AG045390]
- PDF Parkinson's Disease Foundation Research Center Grant [CU08-7254]
- NIH/NINDS [1R01NS076837-01A1]
- HDSA
- NIH/NHGRI Center for Research on Ethical, Legal and Social Implications of Psychiatric, Neurologic and Behavioral Genetics [P50 5P50HG007257-02]
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Young-onset dementia is hereditary, multifactorial, or sporadic. The most common hereditary dementias include Alzheimer disease, frontotemporal degeneration, Huntington disease, prion diseases, and cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoence-phalopathy. Careful attainment of family history assists with diagnosis and determining the likelihood of a genetic cause, and can direct genetic testing. The type of genetic testing depends on confidence in the diagnosis, patient's and affected relatives' symptoms, and the number of disease genes. Single gene, disease-specific gene panels, and large dementia panels are available. Genetic counseling should be given and informed consent obtained. Predictive testing follows the Huntington disease protocol.
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