Journal
ANNALES DE BIOLOGIE CLINIQUE
Volume 73, Issue 3, Pages 315-322Publisher
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/abc.2015.1047
Keywords
vascular calcification; pyrophosphate; matrix Gla protein; fetuin A; calcium sensing receptor
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Vascular calcification is a marker of cardiovascular risk increase. Age and specific disease such as diabetes or chronic kidney disease are important factors for calcification genesis. Vascular calcification process is a complex phenomenon, involving several activators and inhibitors factors. Indeed, recent works related to in vitro and in vivo experimental studies have led to a better understanding of calcification process and identification of molecules able to modulate this system. This revue will summarize some of these molecules with a particular interest of those with therapeutic relevance. We will present: i) calcium sensing receptor and its modulation by cinacalcet; ii) pyrophosphate supplementation; iii) fetuin A and overall propensity serum test for calcification and finally; iv) matrix-Gla-protein and the use of vitamin K to prevent vascular calcification progression.
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