Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 60, Issue -, Pages 202-208Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2018.04.020
Keywords
Tributyltin; Obesity; Dyslipidemia; Gut microbiome dysbiosis; 16S ribosomal RNA
Funding
- Shandong Provincial Natural Science Foundation, China [ZR2014HM104]
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Gut microbiome dysbiosis plays a profound role in the pathogenesis of obesity and tributyltin (TBT) has been found as an environmental obesogen. However, whether TBT could disturb gut microbiome and the relationship between obesity induced by TBT exposure and alteration in gut microbiota are still unknown. In order to assess the association between them, mice were exposed to TBTC1 (50 mu g kg(-1)) once every three days from postnatal days (PNDs) 24 to 54. The results demonstrated that TBT exposure resulted in increased body weight gain, lager visceral fat accumulation and dyslipidemia in male mice on PND 84. Correspondingly, 16S rRNA gene sequencing revealed that TBT treatment decreased gut microbial species and perturbed the microbiome composition in mice. Furthermore, Pearson's corelation coefficient analysis showed a significantly negative correlation between the body weight and the alpha diversity of gut microbiome. These results suggested that TBT exposure could induce gut microbiome dysbiosis in mice, which might contribute to the obesity pathogenesis.
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