Journal
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Volume 37, Issue 4, Pages 1175-1181Publisher
WILEY
DOI: 10.1002/etc.4068
Keywords
Comparative pharmacokinetics; Alternative toxicity testing; Pharmaceutical; Fish embryo toxicity test; Bioconcentration; Development
Categories
Funding
- US National Science Foundation [CHE-1339637]
- US Environmental Protection Agency
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1339637] Funding Source: National Science Foundation
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The zebrafish fish embryo toxicity (FET) test is increasingly employed for alternative toxicity studies, yet our previous research identified increased sensitivity of zebrafish slightly older than embryos employed in FET methods (0-4 d postfertilization [dpf]). We identified rapid steady-state accumulation of diphenhydramine across zebrafish embryo and larval stages. However, significantly (p < 0.05) lower accumulation was observed at 48 h compared to 96 h in chorionated and dechorionated embryos (0-4 dpf), but not in zebrafish at 7 to 11 and 14 to 18 dpf. Increased uptake and toxicity of diphenhydramine was further observed in zebrafish at 7 to 11 and 14 to 18 dpf compared with 0-4 dpf embryos with chorion or dechorionated, which indicates that differential zebrafish sensitivity with age is associated with accumulation resulting from gill and other toxicokinetic and toxicodynamic changes during development. (C) 2017 SETAC
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