Journal
COMPREHENSIVE PHYSIOLOGY
Volume 5, Issue 3, Pages 1265-1280Publisher
WILEY
DOI: 10.1002/cphy.c140074
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Categories
Funding
- NHLBI [HL116524, HL081613]
- NIGMS [GM112806]
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development
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Platelets are anucleate blood cells, long known to be critically involved in hemostasis and thrombosis. In addition to their role in blood clots, increasing evidence reveals significant roles for platelets in inflammation and immunity. However, the notion that platelets represent immune cells is not broadly recognized in the field of Physiology. This article reviews the role of platelets in inflammation and immune responses, and highlights their interactions with other immune cells, including examples of major functional consequences of these interactions. Published 2015.
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