Journal
ENVIRONMENTAL POLLUTION
Volume 232, Issue -, Pages 137-145Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2017.09.026
Keywords
Nitrite; Salinity; Obscure puffer; Oxidative stress; Hematological parameters
Categories
Funding
- National Natural Science Foundation of China [31370429]
- Graduate Training Innovative Projects Foundation of Jiangsu Province [KYZZ16_0458]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Nitrite is a common pollutant in water and is highly toxic to aquatic animals. To reveal the mechanism of salinity in attenuating nitrite toxicity to fish, we measured the physiological responses of juvenile Takifugu obscurus exposed to nitrite concentrations (0, 10, 20, 50, and 100 mg/L) under different salinity levels (0,10, and 20 ppt) for 96 h. Salinity increased the survival rates of juvenile T. obscurus exposed to nitrite. Changes in key hematological parameters, antioxidant system, malondialdehyde, Na+/K+ ATPase, and HSP70 indicated that nitrite induced considerable damage to juveniles; salinity mitigated the harmful effects. This finding reflects similar changing trends in both antioxidants and their gene expressions among different tissues. We applied an overall index, an integrated biomarker response (IBR), that increased under high nitrite condition but recovered to the normal levels under salinity treatment. Analysis of the selected detection indices and IBR values showed that the overall mitigating effect of salinity on nitrite toxicity seems to be at sub-cellular level and associated with complicated physiological responses. (C) 2017 Elsevier Ltd. All rights reserved.
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