Journal
FRONTIERS IN NEUROENDOCRINOLOGY
Volume 38, Issue -, Pages 65-72Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2015.04.001
Keywords
Maternal behavior; Anxiety; Motivation; Medial preoptic area; Bed nucleus of the stria terminalis; Postpartum mood
Categories
Funding
- NIMH
- Foundation of Hope
- Klarman Family Foundation
- Brain and Behavior Research Foundation
- National Institute on Drug Abuse [DA032750, DA038168]
- [T32MH093315]
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Postpartum neuropsychiatric disorders are a major source of morbidity and mortality and affect at least 10% of childbearing women. Affective dysregulation within this context has been identified in association with changes in reproductive steroids. Steroids promote maternal actions and modulate affect, but can also destabilize mood in some but not all women. Potential brain regions that mediate these effects include the medial preoptic area (mPOA) and ventral bed nucleus of the stria terminalis (vBNST). Herein, we review the regulation of neural activity in the mPOA/vENST by environmental and hormonal concomitants in puerperal females. Such activity may influence maternal anxiety and motivation and have significant implications for postpartum affective disorders. Future directions for research are also explored, including physiological circuit-level approaches to gain insight into the functional connectivity of hormone-responsive maternal circuits that modulate affect. (C) 2015 Elsevier Inc. All rights reserved.
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