Journal
ENVIRONMENTAL POLLUTION
Volume 237, Issue -, Pages 559-568Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2018.02.065
Keywords
Breast cancer; Case-control study; Residential proximity; Industrial pollution; Pesticides; Endocrine disrupting chemicals
Categories
Funding
- Accion Transversal del Cancer
- Scientific Foundation of the Spanish Association Against Cancer (Fundacion Cientifica de la Asociacian Espanola Contra el Cancer (AECC)) [EVP-1178/14]
- Spain's Health Research Fund (Fondo de Investigacion Sanitaria) [FIS 12/01416]
- Institute de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, 13509/01286-Leen, PS09/00773-Cantabria, PS09/02078-Huelva, PS09/01903-Valencia, PS09/01662-Granada]
- ICGC International Cancer Genome Consortium CLL (Spanish Ministerio de Economia y Competitividad (MINECO) through the Institute de Salud Carlos III (ISCIII))
- ICGC International Cancer Genome Consortium CLL (Spanish Ministerio de Economia y Competitividad (MINECO) through the Red Tematica de Investigacion del Cancer (RTICC) del ISCIII) [RD12/0036/0036]
- Fundacion Marques de Valdecilla [API 10/09]
- Consejeria de Salud of the Junta de Andalucia [PI-0571-2009, PI-0306-2011, salud201200057018tra]
- Junta de Castilla y Leon [LE22A10-2]
- Conselleria de Sanitat of the Generalitat Valenciana [AP_061/10]
- Regional Government of the Basque Country
- Recercaixa [2010ACUP 00310]
- European Commission [FOOD-CT-2006-036224-HIWATE]
- Spanish Association Against Cancer (AECC) Scientific Foundation
- Catalan Government DURSI [2017SGR723]
- University of Oviedo
- Fundacion Caja de Ahorros de Asturias
- [PI11/01403]
- [PI11/01889-FEDER]
- [PI11/00226]
- [PI11/01810]
- [PI11/02213]
- [PI12/00488]
- [PI12/00265]
- [PI12/01270]
- [PI12/00715]
- [PI12/00150]
- [PI14/01219]
- [PI14/00613]
- [PI15/00069]
- [PI15/00914]
- [PI15/01032]
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Breast cancer is the most frequent tumor in women worldwide, although well-established risk factors account for 53%-55% of cases. Therefore, other risk factors, including environmental exposures, may explain the remaining variation. Our objective was to assess the relationship between risk of breast cancer and residential proximity to industries, according to categories of industrial groups and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Using the current residence of cases and controls, this study was restricted to small administrative divisions, including both breast cancer cases (452) and controls (1511) in the 10 geographical areas recruiting breast cancer cases. Distances were calculated from the respective woman's residences to the 116 industries located in the study area. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (between 1 km and 3 km) to industrial plants, adjusting for matching variables and other confounders. Excess risk (OR; 95%CI) of breast cancer was found near industries overall (1.30; 1.00-1.69 at 3 km), particularly organic chemical industry (2.12; 1.20-3.76 at 2.5 km), food/beverage sector (1.87; 1.26-2.78 at 3 km), ceramic (4.71; 1.62-13.66 at 1.5 km), surface treatment with organic solvents (2.00; 1.23-3.24 at 3 km), and surface treatment of plastic and metals (1.51; 1.06-2.14 at 3 km). By pollutants, the excess risk (OR; 95% CI) was detected near industries releasing pesticides (2.09; 1.14-3.82 at 2 km), and dichloromethane (2.09; 1.28-3.40 at 3 km). Our results suggest a possible increased risk of breast cancer in women living near specific industrial plants and support the need for more detailed exposure assessment of certain agents released by these plants. (C) 2018 Elsevier Ltd. All rights reserved.
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