Journal
ENVIRONMENT INTERNATIONAL
Volume 119, Issue -, Pages 334-345Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2018.06.025
Keywords
Air pollution; Untargeted metabolomics; Metabolic pathways; Adult-onset asthma; Cardio-cerebrovascular diseases
Categories
Funding
- FP7 of the European Commission Enhanced exposure 36 assessment and omic profiling for high priority environmental exposures in Europe (EXPOsOMICS grant) [308610]
- Swiss National Science Foundation [33CS30-148470/12]
- Italian Association for Cancer Research (AIRC)
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Background: Epidemiologic evidence indicates common risk factors, including air pollution exposure, for respiratory and cardiovascular diseases, suggesting the involvement of common altered molecular pathways. Objectives: The goal was to find intermediate metabolites or metabolic pathways that could be associated with both air pollutants and health outcomes (meeting-in-the-middle), thus shedding light on mechanisms and reinforcing causality. Methods: We applied a statistical approach named `meet-in-the-middle' to untargeted metabolomics in two independent case-control studies nested in cohorts on adult-onset asthma (AOA) and cardio-cerebrovascular diseases (CCVD). We compared the results to identify both common and disease-specific altered metabolic pathways. Results: A novel finding was a strong association of AOA with ultrafine particles (UFP; odds ratio 1.80 [1.26, 2.55] per increase by 5000 particles/cm(3)). Further, we have identified several metabolic pathways that potentially mediate the effect of air pollution on health outcomes. Among those, perturbation of Linoleate metabolism pathway was associated with air pollution exposure, AOA and CCVD. Conclusions: Our results suggest common pathway perturbations may occur as a consequence of chronic exposure to air pollution leading to increased risk for both AOA and CCVD.
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