Journal
EUROPEAN JOURNAL OF DERMATOLOGY
Volume 25, Issue -, Pages 18-22Publisher
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/ejd.2015.2550
Keywords
keratinocytes; fibroblasts; dendritic cell; arthropod saliva; vector-borne diseases; leishmaniasis; Lyme borreliosis
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Funding
- conseil regional d'Alsace [2012.60.0033]
- direction generale de l'armement
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In the last years, the skin has been described as a major interface in arthropod borne diseases. Although it constitutes an efficient immune and physical barrier, pathogens have developed effective strategies to thwart the host. In this process, the arthropod plays a major role. For mosquitoes, the quick blood meal is made through an efficient inoculation process directly into the blood vessel. For the long lasting blood meal of hard ticks, the sophisticated biting pieces and the tick saliva provide potent tools to help pathogen transmission. Lyme borreliosis and leishmaniases have been particularly well investigated in this context.
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