Journal
FRONTIERS IN SYSTEMS NEUROSCIENCE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnsys.2015.00120
Keywords
dentate gyrus; adult hippocampal neurogenesis; pattern separation; interference; discrimination; generalization; sparseness; feed-back inhibition
Categories
Funding
- NARSAD Young Investigator Award
- Bettencourt-Schueller Foundation
- Philippe Foundation Award
- US National Institutes of Health Biobehavioral Research Awards for Innovative New Scientists (BRAINS) [1-R01MH104175]
- Ellison Medical Foundation New Scholar in Aging
- Whitehall Foundation
- Inscopix Decode
- HSCI Development grants
Ask authors/readers for more resources
The dentate gyrus (DG) of mammals harbors neural stem cells that generate new dentate granule cells (DGCs) throughout life. Behavioral studies using the contextual fear discrimination paradigm have found that selectively augmenting or blocking adult hippocampal neurogenesis enhances or impairs discrimination under conditions of high, but not low, interference suggestive of a role in pattern separation. Although contextual discrimination engages population-based coding mechanisms underlying pattern separation such as global remapping in the DG and CA3, how adult hippocampal neurogenesis modulates pattern separation in the DG is poorly understood. Here, we propose a role for adult born DGCs in re activation coupled modulation of sparseness through feed-back inhibition to govern global remapping in the DG.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available